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For a given diagnosis, even the best drugs are efficacious only for a fraction of the patients, while a further fraction suffers from adverse effects. This is caused at the same time by individual characteristics in the genetic background, in lifestyle habits, and in variety and severity of the respective disease. Such individual characteristics may concern uptake and elimination of drugs as well as interactions of substances with their target structures.

In order to improve the selection of the optimal remedy for the individual patients and to develop new drug targets, we examine the interaction of various drugs and other chemical entities with clinically relevant enzymes (working group Pietsch), transporters (working group Gründemann) and ion channels (working group  Matthes). To optimize individual dosing, we study the metabolism of drugs as well as drug-drug interactions and develop mathematical-statistical models describing pharmacokinetic-pharmacodynamic relationships (working group Fuhr). With emphasis on the optimization of treatment with anti-infectives and with direct oral anticoagulants in preterm and full-term infants, children and adults in intensive care units, we assess the options of therapeutic drug monitoring (working group Müller).