Therapeutisches Drug Monitoring

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Ausgewählte Publikationen
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Ausgewählte Publikationen


Nies RJ, Müller C, Pfister R, Binder PS, Nosseir N, Nettersheim FS, Kuhr K, Wiesen MHJ, Kochanek M, Michels G. Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients.
J Intensive Care. 2018 14;6:62. doi: 10.1186/s40560-018-0331-7. PMID: 30302254

Linnerz K, Wiesen MHJ, Blaich C, Junghaenel-Welzing S, Welzing L, Roth B, Müller C.
Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Fentanyl and its Major Metabolite Norfentanyl in Critically Ill Neonates.
J Chromatograph Separat Techniq 2015 S6:004.

Hünseler C, Müller C, Roth B.
The authors reply.
Pediatr Crit Care Med. 2015 16(1):93-4. doi: 10.1097/PCC.0000000000000294. PMID: 25560291

Nosseir NS, Michels G, Binder P, Wiesen MH, Müller C.
Simultaneous detection of ketamine, lorazepam, midazolam and sufentanil in human serum with liquid chromatography-tandem mass spectrometry for monitoring of analgosedation in critically ill patients.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 15;973C:133-141. doi: 10.1016/j.jchromb.2014.10.006. PMID: 25464106


Johannsen JO, Reuter H, Hoffmann F, Blaich C, Wiesen MHJ, Streichert T, Müller C.
Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension.
J Pharm Biomed Anal. 2019 Feb 5;164:373-381. doi: 10.1016/j.jpba.2018.11.002. PMID: 30439665


Müller C, Fietz C, Koehler P, Sibley G, Nforbugwe ACA, Streichert T, Wiesen MHJ.
Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Olorofim (F901318), a Novel Antifungal Drug, in Human Plasma and Serum.
Antimicrob Agents Chemother. 2018 24;62(11). pii: e01356-18. doi: 10.1128/AAC.01356-18. PMID: 30150474

Gastine S, Lehrnbecher T, Müller C, Farowski F, Bader P, Ullmann-Moskovits J, Cornely OA, Groll AH, Hempel G. Pharmacokinetic Modeling of Voriconazole To Develop an Alternative Dosing Regimen in Children.
Antimicrob Agents Chemother. 2017 21;62(1). pii: e01194-17. doi: 10.1128/AAC.01194-17. PMID: 29038273

Müller C, Gehlen D, Blaich C, Prozeller D, Liss B, Streichert T, Wiesen MHJ. Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum.
Ther Drug Monit. 2017 39(5):505-513. doi: 10.1097/FTD.0000000000000438. PMID: 28742650

Strenger V, Farowski F, Müller C, Hofer N, Dornbusch HJ, Sperl D, Lackner H, Benesch M, Urban C. Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses.
Int J Antimicrob Agents. 2017 50(2):272-275. doi: 10.1016/j.ijantimicag.2017.02.024. PMID: 28527634

Bochennek K, Balan A, Müller-Scholden L, Becker M, Farowski F, Müller C, Groll AH, Lehrnbecher T. Micafungin twice weekly as antifungal prophylaxis in paediatric patients at high risk for invasive fungal disease.
J Antimicrob Chemother. 2015 70(5):1527-30. doi: 10.1093/jac/dku544. PMID: 25564562


Fietz C, Michels G, Müller C, Wiesen MHJ. Monitoring of Apixaban in a Super Obese Patient.
Am J Med. 2019 132(1):e15-e16. doi: 10.1016/j.amjmed.2018.08.021. PMID: 30201245

Sennesael AL, Larock AS, Douxfils J, Elens L, Stillemans G, Wiesen M, Taubert M, Dogné JM, Spinewine A, Mullier F. Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study.
Thromb J. 2018 12;16:28. doi: 10.1186/s12959-018-0183-3. PMID: 30455596

Wiesen MHJ, Blaich C, Taubert M, Jennissen V, Streichert T, Pfister R, Michels G. Residual rivaroxaban exposure after discontinuation of anticoagulant therapy in patients undergoing cardiac catheterization.
Eur J Clin Pharmacol. 2018 74(5):611-618. doi: 10.1007/s00228-018-2421-9. PMID: 29376194

Wiesen MHJ, Michels G. [NOAKs in Obese Patients - No Problem?]
Dtsch Med Wochenschr. 2018 143(2):129. doi: 10.1055/s-0043-122701. PMID: 29359293

Wiesen MHJ, Blaich C, Streichert T, Michels G, Müller C. Paramagnetic micro-particles as a tool for rapid quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma by UHPLC-MS/MS.
Clin Chem Lab Med. 2017 28;55(9):1349-1359. doi: 10.1515/cclm-2016-0888. PMID: 28328524

Wiesen MH, Blaich C, Müller C, Streichert T, Pfister R, Michels G. The Direct Factor Xa Inhibitor Rivaroxaban Passes Into Human Breast Milk.
Chest. 2016 150(1):e1-4. doi: 10.1016/j.chest.2016.01.021. PMID: 27396794

Blaich C, Müller C, Michels G, Wiesen MH. Multi-analyte analysis of non-vitamin K antagonist oral anticoagulants in human plasma using tandem mass spectrometry.
Clin Chem Lab Med. 2015 53(12):1981-90. doi: 10.1515/cclm-2014-1108. PMID: 25901716


Hackl A, Becker JU, Körner LM, Ehren R, Habbig S, Nüsken E, Nüsken KD, Ebner K, Liebau MC, Müller C, Pohl M, Weber LT. Mycophenolate mofetil following glucocorticoid treatment in Henoch-Schönlein purpura nephritis: the role of early initiation and therapeutic drug monitoring.
Pediatr Nephrol. 2018 33(4):619-629. doi: 10.1007/s00467-017-3846-6. PMID: 29177628

Hackl Á, Cseprekál O, Gessner M, Liebau MC, Habbig S, Ehren R, Müller C, Taylan C, Dötsch J, Weber LT. Mycophenolate Mofetil Therapy in Children With Idiopathic Nephrotic Syndrome: Does Therapeutic Drug Monitoring Make a Difference?
Ther Drug Monit. 2016 38(2):274-9. doi: 10.1097/FTD.0000000000000258. PMID: 2648820


Pfreundschuh M, Poeschel V, Zeynalova S, Hänel M, Held G, Schmitz N, Viardot A, Dreyling MH, Hallek M, Mueller C, Wiesen MH, Witzens-Harig M, Truemper L, Keller U, Rixecker T, Zwick C, Murawski N. Optimization of rituximab for the treatment of diffuse large B-cell lymphoma (II): extended rituximab exposure time in the SMARTE-R-CHOP-14 trial of the german high-grade non-Hodgkin lymphoma study group.
J Clin Oncol. 2014 20;32(36):4127-33. doi: 10.1200/JCO.2013.54.6861. PMID: 25403207

Pfreundschuh M, Müller C, Zeynalova S, Kuhnt E, Wiesen MH, Held G, Rixecker T, Poeschel V, Zwick C, Reiser M, Schmitz N, Murawski N. Suboptimal dosing of rituximab in male and female patients with DLBCL.
Blood. 2014 30;123(5):640-6. doi: 10.1182/blood-2013-07-517037. PMID: 24297867

Nosseir NS, Michels G, Pfister R, Adam R, Wiesen MH, Müller C. [Therapeutic Drug Monitoring of antiinfectives in intensive care medicine].
Dtsch Med Wochenschr. 2014 139(38):1889-94. doi: 10.1055/s-0034-1387215. PMID: 25203549